Colorectal Cancer Stem Cell Markers

There has been accumulating evidence in support of the cancer stem cell csc concept of cancer which proposes that cscs are central in the initiation of cancer. Colorectal cancer crc is the second most common cancer in women and the third most common in men. This article reviews the current knowledge in these cancer stem cell markers and future directions of this field of research.

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This topic remains highly controversial due to the lack of widely accepted specific molecular markers.

Colorectal cancer stem cell markers.

Wnt and mammalian target of rapamycin mtor are major molecular signaling pathways associated with the development and progression of tumor as well as the maintenance and proliferation of cancer stem cells cscs in colorectal cancer crc. Colorectal cancer stem cells cr cscs markers identification and localization of cr cscs through different markers is difficult as well as highlighting different pathways disrupted in crc. Adenocarcinoma accounts for 90 of crc cases. This marker has been investigated to better understand the characteristics and functions of cancer stem cells.

Cd133 a five transmembrane glycoprotein is widely used as a marker to identify and isolate colorectal cancer stem cells. 1 hunan key laboratory of translational radiation. The cancer stem cell concept of cancer is an emerging paradigm with accumulating supporting evidence in recent years. Cancer stem cells in colorectal cancer are characterised by their expression of multiple markers.

1 hunan key laboratory of translational radiation oncology hunan cancer hospital and the affiliated cancer hospital of xiangya. Cancer stem cells in progression of colorectal cancer.

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